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Anti-CD89 Antibody

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Absea Biotechnology
Name: Anti-CD89 Antibody
Description: Mouse monoclonal (MIP8a) antibody to CD89.
Applications: FACS, IF
Reactivity: Human
Immunogen: Soluble CD89.
Host: Mouse
Clonality: Monoclonal
Clone: MIP8a
Isotype: IgG1
Conjugate: Unconjugated
Purification: IgG is purified through a Protein A column.
Concentration: 1 mg/ml in PBS containing 0.09% sodium azide as a preservative.
Storage: 4 °C for 1 month, -20 °C or -80°C in aliquots. Avoid repeated freeze/thaw cycles.

Target (Information from UniProt)
Function: Binds to the Fc region of immunoglobulins alpha. Mediates several functions including cytokine production.
Tissue Specificity: Isoform A.1, isoform A.2 and isoform A.3 are differentially expressed between blood and mucosal myeloid cells. Isoform A.1, isoform A.2 and isoform A.3 are expressed in monocytes. Isoform A.1 and isoform A.2 are expressed in alveolar macrophages; however only one isoform is expressed at alveolar macrophages surfaces.
Cellular Location: Cell membrane.
UniProt: P24071
Gene ID: 2204
Synonyms: Fc alpha receptor Antibody
Fc fragment of IgA, receptor for Antibody
FCAR Antibody
IgA Fc receptor Antibody
Immunoglobulin alpha Fc receptor Antibody

Validation Data - Anti-CD89 Antibody from Absea Biotechnology (010008A01) - Antibody Supply Service
Neutrophil phagocytosis of IgA immune complexes in presence or absence (control) of MIP8a.

Product Citations

Peng M et al. Endocytosis of FcalphaR is clathrin and dynamin dependent, but its cytoplasmic domain is not required. Cell Res 20(2) : 223-37 (2010).

Zhang W et al. Neutrophil lactoferrin release induced by IgA immune complexes differed from that induced by cross-linking of fcalpha receptors (FcalphaR) with a monoclonal antibody, MIP8a. Clin. Exp. Immunol. 121(1) : 106-111 (2000)

Product Code - 010008A01
Size Price Quantity
100µg £178
200µg £259
1mg £682

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