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Anti-SMC3 Antibody

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Absea Biotechnology
Name: Anti-SMC3 Antibody
Description: Rat monoclonal (KT75) antibody to SMC3.
Applications: WB
Reactivity: Mouse
Immunogen: Recombinant mouse SMC3 (aa177 - aa420).
Amino Acid Start: 177
Amino Acid End: 420
Host: Rat
Clonality: Monoclonal
Clone: KT75
Isotype: IgG2a
Conjugate: Unconjugated
Purification: Antibody is purified from culture supernatant using a protein G column.
Concentration: 1 mg/ml in PBS containing 0.09% sodium azide as a preservative.
Storage: 4 °C for 1 month, -20 °C or -80°C in aliquots. Avoid repeated freeze/thaw cycles.

Target (Information from UniProt)
Function: Central component of cohesin, a complex required for chromosome cohesion during the cell cycle. The cohesin complex may form a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. Cohesion is coupled to DNA replication and is involved in DNA repair. The cohesin complex plays also an important role in spindle pole assembly during mitosis and in chromosomes movement.
Tissue Specificity: Widely expressed, with higher expression in testis and brain.
Sequence Similarities: Belongs to the SMC family. SMC3 subfamily.
Post-Translational Modification: Phosphorylated at Ser-1083 in a SPO11-dependent manner.
Cellular Location: Nucleus. Chromosome. Chromosome > Centromere.

Associates with chromatin. Before prophase it is scattered along chromosome arms. During prophase, most of cohesin complexes dissociate from chromatin probably because of phosphorylation by PLK, except at centromeres, where cohesin complexes remain. At anaphase, the RAD21 subunit of the cohesin complex is cleaved, leading to the dissociation of the complex from chromosomes, allowing chromosome separation. The phosphorylated form at Ser-1083 is preferentially associated with unsynapsed chromosomal regions.
UniProt: Q9CW03
Gene ID: 13006
Synonyms: BAM Antibody
Bamacan Antibody
Basement membrane associated chondroitin proteoglycan Antibody
Basement membrane-associated chondroitin proteoglycan Antibody
BMH Antibody
CDLS3 Antibody
Chondroitin sulfate proteoglycan 6 Antibody
chondroitin sulfate proteoglycan 6 (bamacan) Antibody
Chromosome associated polypeptide Antibody
Chromosome-associated polypeptide Antibody
CSPG 6 Antibody
CSPG6 Antibody
hCAP Antibody
Human chromosome associated polypeptide Antibody
im:7142991 Antibody
SMC 3 Antibody
SMC protein 3 Antibody
SMC-3 Antibody
SMC3 (phospho S1083) Antibody
SMC3 (phospho S383) Antibody
SMC3L1 Antibody
SMC3_HUMAN Antibody
Structural maintenance of chromosome 3 Antibody
Structural maintenance of chromosomes 3 Antibody
Structural maintenance of chromosomes protein 3 Antibody
u:fb22e01 Antibody
wu:fc30d07 Antibody

Product Code - 061518B06
Size Price Quantity
100µg £186
200µg £273
1mg £730

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