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Anti-TNF Alpha (TNFα) Antibody (HRP)

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Absea Biotechnology
040105F11H
Overview
Name: Anti-TNF Alpha (TNFα) Antibody (HRP)
Description: Mouse monoclonal (KT31) antibody to TNF alpha (TNFα) (HRP)
Applications: sELISA 
Antigen: TNF alpha (TNFα)
Protein Length: 146
Amino Acid Start: 87
Amino Acid End: 232
Host: Mouse
Clonality: Monoclonal
Clone: KT31
Isotype: IgG2a
Conjugate: HRP

Target (Information from UniProt)
Function: Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation. Impairs regulatory T-cells (Treg) function in individuals with rheumatoid arthritis via FOXP3 dephosphorylation. Upregulates the expression of protein phosphatase 1 (PP1), which dephosphorylates the key 'Ser-418' residue of FOXP3, thereby inactivating FOXP3 and rendering Treg cells functionally defective (PubMed:23396208). Key mediator of cell death in the anticancer action of BCG-stimulated neutrophils in combination with DIABLO/SMAC mimetic in the RT4v6 bladder cancer cell line (PubMed:22517918).
Involvement in Disease: Psoriatic arthritis: An inflammatory, seronegative arthritis associated with psoriasis. It is a heterogeneous disorder ranging from a mild, non-destructive disease to a severe, progressive, erosive arthropathy. Five types of psoriatic arthritis have been defined: asymmetrical oligoarthritis characterized by primary involvement of the small joints of the fingers or toes; asymmetrical arthritis which involves the joints of the extremities; symmetrical polyarthritis characterized by a rheumatoid like pattern that can involve hands, wrists, ankles, and feet; arthritis mutilans, which is a rare but deforming and destructive condition; arthritis of the sacroiliac joints and spine (psoriatic spondylitis).
Sequence Similarities: Belongs to the tumor necrosis factor family.
Post-Translational Modification: The soluble form derives from the membrane form by proteolytic processing. The membrane-bound form is further proteolytically processed by SPPL2A or SPPL2B through regulated intramembrane proteolysis producing TNF intracellular domains (ICD1 and ICD2) released in the cytosol and TNF C-domain 1 and C-domain 2 secreted into the extracellular space.
Cellular Location: Cell membrane.
UniProt: P01375
Gene ID: 7124
Synonyms: APC1 Antibody
APC1 protein Antibody
Cachectin Antibody
DIF Antibody
Differentiation inducing factor Antibody
Macrophage cytotoxic factor Antibody
Tnf Antibody
TNF superfamily, member 2 Antibody
TNF, macrophage derived Antibody
TNF, monocyte derived Antibody
TNF-a Antibody
TNF-alpha Antibody
TNFA Antibody
TNFA_HUMAN Antibody
TNFSF2 Antibody
Tumor necrosis factor Antibody
Tumor necrosis factor alpha Antibody
Tumor necrosis factor ligand superfamily member 2 Antibody
Tumor Necrosis Factor, Membrane Form Antibody
Tumor necrosis factor, soluble form Antibody

Product Code - 040105F11H
Size Price Quantity
100µg £186
200µg £273
1mg £730

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